ASP.NET Core Blazor uses the generic app hosting in ASP.NET Core 3+ but the two hosting models have slightly different integrations.

Server-side implementations are configured in exactly the same way as any other ASP.NET Core 3 application.

Client-side injection is slightly more restricted due to requirements for WebAssembly hosting.

This example for WebAssembly works as of March 30, 2021 with .NET 5. Example:

public class Program
  public static async Task Main(string[] args)
      var builder = WebAssemblyHostBuilder.CreateDefault(args);
      builder.ConfigureContainer(new AutofacServiceProviderFactory(ConfigureContainer));


      await builder.Build().RunAsync();

  private static void ConfigureContainer(ContainerBuilder builder)
    // add any registrations here

Once registered, Blazor components can use dependency injection via the standard @inject Razor directive.